Email: tuthdirector@iom.edu.np   Phone: 01-4412404 (1028)   P.O. Box:3578

  • Dr. Laxman Prasad Shrestha
  • Professor
  • Department of Pediatrics
  • laxmanshree12@gmail.com
  • Academic Achievements
    • Medical doctor in Pediatrics, India Institute of Medical Sciences, New Delhi, India, 1994
  • Memberships
    • 2014- Current Chair, Subject committee of Pediatrics and Obstetrics and gynaecology, Institute of Medicine
    • 2014- Current Member, Faculty board, IOM
    • 2014-2016 Immediate Past President, Nepal Paediatric Society
    • 2009 -current Member, Technical Working Group, HIV/AIDS, National Centre for AIDS and HIV and D STD control, Ministry of Health, Government of Nepal
    • 1995 – current Life Member, National Neonatology Forum, India
    • 2000 – current Life Member, Perinatal Society of Nepal
    • 2016-2018 Member, Advisory Board of Members of Asia Pacific Pediatric Association (APPA)
  • Research Activities
    • 2018-2019 Cross-sectional study to assess persistence of immunity conferred by a single IPV dose administered in the EPI routine immunization schedule with joint collaboration with Polio Eradication Department, World Health Organization, Geneva, Switzerland and Immunization Division, Centre for Disease Control and Prevention, Atlanta, USA
    • 2016-2019 Zinc as an adjunct for the treatment of clinical severe infection in infants younger than 2 months with joint collaboration with Translational Health Science and Technical Institute, India, Centre for International Health, Norway Stanford University School of Medicine, USA and Institute of Medicine, Tribhuvan University, Nepal
    • 2017-2019 Supplementation of vitamin B12 in pregnancy and postpartum on growth and neurodevelopment in early childhood: A Randomized, Placebo Controlled Trial among pregnant women in Bhaktapur, Nepal” in collaboration Centre for International Health, University of Bergen and Institute of Medicine, Kathmandu
      2017-2019 A community based double blind randomized clinical trial, “The effect of vitamin B12 supplementation in Nepalese infants on growth and development in Nepalese Children- Extended follow-up” in collaboration Centre for International Health, University of Bergen and Institute of Medicine.
    • 2017-2020 Implementation of Chronic Obstructive Pulmonary Disease case Finding and Self-Management Action Plans in Bhaktapur, Nepal in collaboration with University College of London, John Hopkins School of Public Health and Institute of Medicine.
    • 2015-2017 Co-investigator of multicentric study on “Etiology, Risk Factors and Interactions of Enteric Infections and Malnutrition and the Consequences for Child Health and Development in Nepal” with joint collaboration of Institute of Medicine, Henry M Jackson Foundation, Bethesda, USA, Walter Reed AFRIMS Research Unit Nepal, Armed Forces Research Institute of Medical Sciences, Thailand
    • 2010-2017 Co-investigator of study “Impact of massage with sunflower seed oil on morbidity and mortality of newborns in Sarlahi, Nepal” with joint collaboration of Institute of Medicine, Nepal Nutrition Intervention Project and John Hopkins University.
    • 2015-2016 Principle investigator of study on “Measuring the impact of routine use of pneumococcal conjugate vaccine (PCV) on hospitalizations for pneumonia, meningitis, and sepsis in Nepalese children” conducted by Nepal Paediatric Society in collaboration with Agence de Médecine Préventive, Paris, France.
    • 2015-2016 Principle investigator of study on “Economic evaluation of pneumococcal disease and pneumococcal vaccine in Nepal: A sub-study of the Pneumococcal vaccine Nepal Impact Assessment (The PneumoNIA) study” conducted by Nepal Paediatric Society with collaboration with International Vaccine Access Center (IVAC), Johns Hopkins University, Baltimore, USA
    • 2013-2014 Principle investigator of study on “Effect of introduction of Hemophilus influenzae type b Vaccine in national Immunization Schedule on Hospitalization rates for Pneumonia/ Severe bacterial infection in Nepalese Children” conducted by the Nepal Paediatric Society in collaboration with John Hopkins Bloomberg School of Public Health, Baltimore, USA
    • 2011-2014 Co-Principal investigator of “Field Trial of Maternal Influenza Immunization in Nepal: Mother’s Gift – Nepal Field Trial in Sarlahi, Nepal” with joint collaboration of Institute of Medicine, Nepal Nutrition Intervention Project and John Hopkins University.
    • 2011-2013 Principle investigator of study on “The effect diarrheal disease on oral Polio vaccine seroconversion in Nepali children” with joint collaboration of Institute of Medicine, Central for Disease Control(CDC) Atlanta, WHO, UNICEF, and Child Health Division, Ministry of Health.
    • 2010-2011 Co-investigator of study “Improved Community- based diagnosis of Acute Lower Respiratory Illness” with joint collaboration of Institute of Medicine, Nepal Nutrition Intervention Project and John Hopkins University.
  • Publications
    1. Implementation of COPD case finding and self-management action plans in low- and middle-income countries: global excellence in COPD outcomes (GECo) study protocol; Siddharthan et al.Trials (2018) Dec 19:571
    2. Primary and Repeated Respiratory Viral Infections Among Infants in Rural Nepal; Jim Boonyaratanakornkit et al Journal of the Pediatric Infectious Diseases Society November 2018 DOI: 10.1093/jpids/piy107
    3. Effect of Nasopharyngeal Pneumococcal Carriage on RSV and hMPV Illness Severity in Infants in Nepal; Alastair Murray et al November 2018 Open Forum Infectious Diseases 5(suppl 1):S4-S4 DOI: 10.1093/ofid/ofy209.008
    4. Transmission of Influenza Virus in Mother and Infant Transmission Events in Nepal; Emily Scott et al November 2018 Open Forum Infectious Diseases 5(suppl_1):S223-S224 DOI: 10.1093/ofid/ofy210.620
    5. Improving the quality of maternity services in Nepal through accelerated implementation of essential interventions by healthcare professional associations; Int J Gynecol Obstet 2018; 1–8,2018; DOI: 10.1002/ijgo.12678
    6. Measles and Rubella Seroprevalence in Mother–Infant Pairs in Rural Nepal and the United States: Pre- and Post-Elimination Populations; Steven C Leclerq September 2018 The American journal of tropical medicine and hygiene 99(5) DOI: 10.4269/ajtmh.17-0836
    7. Acceptability and Reliability of the Bayley Scales of Infant and Toddler Development-III Among Children in Bhaktapur, Nepal; Suman Ranjitkar July 2018 Frontiers in Psychology 9:1265 DOI: 3389/fpsyg.2018.01265
    8. Cobalamin and Folate Status among Breastfed Infants in Bhaktapur, Nepal
    9. Burden and risk factors for coronavirus infections in infants in rural Nepal, S M Iftekhar Uddin et al
    10. Impact of timing of influenza vaccination in pregnancy on transplacental antibody transfer, influenza incidence and birth outcomes; a randomized trial in rural Nepal February 2018 Clinical Infectious Diseases DOI 10.1093/cid/ciy090
    11. Impact of maternal vaccination timing and influenza virus circulation on birth outcomes in rural Nepal Naoko Kozuki, Joanne Katz, Janet A. Englund, Mark C. Steinhoff, Subarna K. Khatry, Laxman Shrestha, Jane Kuypers, Luke C. Mullany, Helen Y. Chu, Steven C. LeClerq, James M. Tielsch Int J Gynecol Obstet ; 2018; 140: 65–72
    12. Zinc as an adjunct treatment for reducing case fatality due to clinical severe infection in young infants: study protocol for a randomized controlled trial Wadhwa et al. BMC Pharmacology and Toxicology  (2017) 18:56  DOI 10.1186/s40360-017-0162-5
    13. Clinical Presentation, Risk Factors, and Cross-Protection from Repeated Respiratory Viral Infections in Infants in Nepal, October 2017; Open Forum Infectious Diseases 4(suppl_1):S458-S458 DOI 10.1093/ofid/ofx163.1168
    14. Transplacental transfer of maternal respiratory syncytial virus (RSV) antibody and protection against RSV disease in infants in rural Nepal Helen Y. Chu, James Tielsch, Joanne Katz, Amalia S. Magaret, Subarna Khatry, Stephen C. LeClerq, Laxman Shrestha, Jane Kuypers, Mark C. Steinhoff, Janet A. Englund Journal of Clinical Virology 95 (2017) 90–95
    15. Neurodevelopmental Outcome of High Risk Babies at One Year of Age Born in a Tertiary Centre Journal of Nepal Paediatric Society 37(1):45; October 2017; DOI 10.3126/jnps.v37i1.16242
    16. Predictors of Measles and Rubella Serostatus in Mother–Infant Pairs in Rural Nepal Open Forum Infectious Diseases 4(suppl_1):S118-S118; October 2017 DOI 10.1093/ofid/ofx163.144
    17. Meterology-driven Prediction of RSV/RHV Incidence in Rural Nepal. Open Forum Infectious Diseases 4(suppl_1):S360-S360; October 2017; DOI 10.1093/ofid/ofx163.873
    18. Human Metapneumovirus and Other Respiratory Viral Infections during Pregnancy and Birth, Nepal. Emerging infectious diseases 23(8):1341-1349 · August 2017 DOI: 10.3201/eid2308.161358
    19. The effect of vitamin B12 supplementation in Nepalese infants on growth and development: study protocol for a randomized controlled trial; Tor A. Strand,  Manjeswori Ulak, Ram K. Chandyo, Ingrid Kvestad4, Mari Hysing, Merina Shrestha, Sudha Basnet, Suman Ranjitkar, Laxman Shrestha and Prakash S. Shrestha; Trials (2017) 18:187 DOI 10.1186/s13063-017-1937-0
    20. Year-round influenza immunization during pregnancy in Nepal: A phase 4, randomised, placebo-controlled trial; Mark C Steinhoff, Joanne Katz, Janet A Englund, Subarna K Khatry, Laxman Shrestha, Jane Kuypers, Laveta Stewart, Luke C Mullany, Helen Y Chu, Steven C LeClerq, Naoko Kozuki, Monica McNeal, Adriana M Reedy, James M Tielsch The Lancet Infectious Diseases, May 2017 DOI: 10.1016/S1473-099(17)30252
    21. Febrile Rhinovirus Illness during Pregnancy Is Associated with Low Birth Weight in Nepal; Open Forum Infect Dis. 2017 Spring; 4(2): ofx073.Published online 2017 April 6. doi:10.1093/ofid/ofx073 Erin K. Philpott, Janet A. Englund, Joanne Katz, James Tielsch, Subarna Khatry, Stephen C. LeClerq, Laxman Shrestha, Jane Kuypers, Amalia S. Magaret, Mark C. Steinhoff, and Helen Y. Chu
    22. Nutritional status of infants at six months of age following maternal influenza immunization: A randomized placebo-controlled trial in rural Nepal. Joanne Katz, Janet A. Englund, Mark C. Steinhoff, Subarna K. Khatry,  Laxman Shrestha, Jane Kuypers,  Luke C. Mullany, Helen Y. Chu, Steven C. LeClerq, Naoko Kozuki,  James M. Tielsch. Vaccine 35 (2017) 6743–6750
    23. Population-Based Pertussis Incidence and Risk Factors in Infants Less Than 6 Months in Nepal;J Pediatric Infect Dis Soc piw079, https://doi.org/10.1093/jpids/piw079, January 10, 2017 Michelle M. Hughes, Janet A. Englund, Jane Kuypers, James M. Tielsch, Subarna K. Khatry, Laxman Shrestha, Steven C. LeClerq, Mark Steinhoff, Joanne Katz.
    24. Paragonimiasis: First autochthonous case report from Nepal,  Journal of Institute of Medicine, Aug.-Dec., 2016, 38:2-3 Sah R, Khadka S, Sherchand JB, Parajuli K, Shah NP, Mishra SK, Sharma S, Shrestha L, Basnet S, Tandukar S, Bhandari D, Yadav SR, Kattel HP, Pokhrel BM1, Rijal B
    25. Pathogen -specific burden of outpatient diarrhea in infants in Nepal: a multisite prospective case-control study,  Journal of the Pediatric Infectious Diseases Society; JPIDS- 2017;00(00):1–11
    26. Clinical Profile and Outcome of Mechanically Ventilated Neonates in a Tertiary Level Hospital, Prabina Shrestha, Srijana Basnet, Laxman Shrestha; Journal of Nepal Paediatric Society 35(3):218, June 2016;DOI: 10.3126/jnps.v35i3.13328
    27. Impact of an improved biomass stove on birth outcomes in rural Nepal: A cluster-randomized, step-wedge trial Annals of Global Health 82(3):576 · May 2016 DOI: 10.1016/j.aogh.2016.04.652
    28. Respiratory Syncytial Virus Infection in Infants in Rural Nepal; May 2016. DOI: 10.1016/j.jinf.2016.05.007; Helen Y. Chu · Joanne Katz, James Tielsch , Subarna K. Khatry · Laxman Shrestha · Steven C. LeClerq , Amalia Magaret, Jane Kuypers, Mark Steinhoff , Janet A. Englund
    29. Effect of an improved biomass stove on acute lower respiratory infections in young children in rural Nepal: a cluster-randomised, step-wedge trial; James M Tielsch, Joanne Katz, Subarna K Khatry, Laxman Shrestha, Patrick Breysse,  Scott Zeger, William Checkley, Luke C Mullany Naoko Kozuki, Steven C LeClerq, Ramesh Adhikari; The Lancet Global Health 4:S19; April 2016
    30. Risk factors and dynamics of household transmission of respiratory syncytial virus and other respiratory viruses in rural Nepal; Emily M Scott · Laveta Stewart · Joanne Katz · James Tielsch ·Jane Kuypers · Subarna K Khatry · Steven C LeClerq · Laxman Shrestha · Mark Steinhoff · Janet A Englund · Helen Y Chu; The Lancet global Health, Volume 4, Special Issue, S28, April 2016 DOI: http://dx.doi.org/10.1016/S2214-109X(16)30033-X
    31. The effect of diarrheal disease on bivalent oral polio vaccine (bOPV) immune response in infants in Nepal. Cristina V. Cardemil, Concepcion Estivariz, Laxman Shrestha, Jeevan B. Sherchand, Arun Sharma, Howard E. Gary Jr., M. Steven Oberstec, William C. Weldon III , Michael D. Bowen, Jan Vinjéc, W. William Schluter, Abhijeet Ananda, Ondrej Macha, Susan Y. Chua,  Vaccine 34 (2016) 2519–2526
    32. Bottlenecks and opportunities for delivering integrated pediatric HIV services in Nepal. Curr Opin HIV AIDS. 2016 Mar;11(1 Suppl 1):S21-9. doi: 10.1097/COH.Diese MShrestha LPradhan BSingh DRaaijmakers HKisesa AChamla DNtambue MA
    33. Clinical Presentation and Birth Outcomes Associated with Respiratory Syncytial Virus Infection in Pregnancy, Helen Y Chu, Joanne KatzJames Tielsch, Subarna K Khatry, Laxman Shrestha, Steven C LeClerq, Amalia Magaret, Jane Kuypers, Mark C Steinhoff, Janet A Englund;  PLOS ONE | DOI:10.1371/journal.pone.0152015 March 31, 2016
    34. Risk factors associated with retinopathy of prematurity among neonates in a tertiary care hospital in Nepal; Shrestha JB, Yadav R, Shrestha JK, Shrestha L, Sah RP. Journal of Kathmandu Medical College, Vol. 5, No. 1, Issue 15, Jan.-Mar., 2016
    35. Infant vaccination timing: Beyond traditional coverage metrics for maximizing impact of vaccine programs, an example from southern Nepal;Michelle M. Hughes, Joanne Katz, Janet A. Englund, Subarna K. Khatry, Laxman Shrestha, Steven C. LeClerq, Mark Steinhoff, James M. Tielsch; http://dx.doi.org/10.1016/j.vaccine.2015.12.061
    36. Designs of two randomized, community-based trials to assess the impact of influenza immunization during pregnancy on respiratory illness among pregnant women and their infants and reproductive outcomes in Rural Nepal James M. Tielsch,  Joanne Katz, Laxman Shrestha et al BMC Pregnancy and Child birth 15(1) December 2015
    37. Low Birth Weight at Term and Its Determinants in a Tertiary Hospital of Nepal: A Case-Control Study; Sudesh Raj Sharma ,Smith Giri, Utsav Timalsina, Sanjiv Sudarshan Bhandari, Bikash Basyal, Kusum Wagle, Laxman Shrestha; Plus one April 8, 2015, DOI: 10.1371/journal.pone.0123962
    38. Streptococcus pneumoniae among children with clinical meningitis in Nepal;  Sherchan, J. B.; Tandukar, S.; Shrestha, L.; Rai, G. K.; Sharma, A.; Gami, F. C.; Rijal, B.; Sherchand, J. B.; Ohara, H; Journal of the Institute of Medicine 37(3):47-52 · December 2015
    39. Designs of Two randomized, community-based trials to assess the impact of alternative cookstove installation on respiratory illness among young children and reproductive outcomes in rural Nepal, James M. Tielsch,  Joanne Katz, Laxman Shrestha et al. BMC Public Health 2014, 14:1271 doi:10.1186/1471-2 458-14-1271
    40. Mortality and morbidity pattern of preterm babies at Tribhuvan University Teaching Hospital  Shrestha L, Shrestha P, Journal of Nepal Paediatric Society, Vol:33, issue 3, Sept-Dec, 2013
    41. Trends in neonatal mortality at tertiary level teaching hospital. Basnet S, Shrestha L, Journal of Nepal Paediatric Society, Vol:33, issue 3, Sept-Dec, 2013
    42. Clinical Profile of children with HIV infection on antiretroviral therapy at TU Teaching Hospital, Shrestha L, Khanal A, Shrestha P; Journal of Institute of Medicine, Vol: 35, issue 3, August 2013
    43. Hospital-based study in children with rotavirus gastroenteritis and other enteropathogens. J Nepal Health Res Counc 2012 Jan;10(20):130-5J B Sherchand , S Tandukar,  J B Sherchan, A Rayamajhi , B Gurung · L Shrestha,  B Rijal , B M Pokhrel
    44. Hospital-Based study I children with Rotavirus gastroenteritis and other enteropathogens. Sherchand JB, Shrestha L et al, Journal of Nepal Health Research Council, Vol 12; No.2, Issue 21; May 2012
    45. Sucrose as an analgesic in relieving procedural pain in neonates, Srijana Basnet, Laxman Shrestha and Prakash S Shrestha, Journal of Neonatal Perinatal Medicine3(2010) 325–331
  • Book Chapters
    • National guideline for early infant diagnosis – Lead author; National Centre for AIDS and STD control,
    • The National guideline for the management of HIV and AIDS in children in Nepal- Lead author,
    • National Consolidated Guidelines for Treating and Preventing HIV in Nepal- Pediatric Chapter, Editions 2014 and 2017.
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